Contraindicated (1)pentobarbital will reduce the level or result of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the development and elimination of cariprazine's Lively metabolites.pentobarbital will lessen the extent or result of estrogens esterified by influencing hepatic/intest